Publications

Selected Publications

  • French C.A., Jin X., Campbell T.G., Gerfen E., Groszer M., Fisher S.E., Costa R.M. (2011). An aetiological Foxp2 mutation causes aberrant striatal activity and alters plasticity during skill learning. Molecular Psychiatry. doi: 10.1038/mp.2011.105
  • Costa R.M. (2011). A selectionist account of de novo action learning. Current Opinion in Neurobiology, 21(4):579-86.
  • Jin X. & Costa R.M. (2010). Start/stop signals emerge in nigrostriatal circuits during sequence learning. Nature, 466(7305): 457-62, doi:10.1038/nature09263
  • Dias-Ferreira E., Sousa J.C., Melo I., Morgado P., Mesquita A.R., Cerqueira J.J., Costa R.M. Sousa N. (2009). Chronic stress causes frontostriatal reorganization and impairs decision making. Science, 325(5940):621-5.
  • Yin H.H., Prasad-Mulcare S., Hilario M.R.F., Clouse E., Davis M.I., Lovinger D.M.., Costa R.M. (2009). Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill. Nature Neuroscience, 12:3.
  • Cui Y., Costa R.M., Murphy G. G., Elgersma Y., Zhu Y., Gutmann D.H., Parada L.F., Mody I., Silva A.J. (2008). Neurofibromin regulation of Ras/ERK signaling modulates GABA release and learning. Cell, 31;135(3):549-60.
  • Hilario M., Clouse E., Yin H.H., Costa R.M. (2007). Endocannabinoid signaling is critical for habit formation. Frontiers in Integrative Neuroscience. 1: 6, doi: 10.3389/neuro.07/006.2007.
  • Costa R.M., Lin S.C., Sotnikova T.D., Cyr M., Gainetdinov R.R., Caron M.G., Nicolelis M.A.L. (2006). Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction. Neuron, 52(2): 359-69.
  • Costa R.M., Drew C. and Silva A.J. (2005). To Remember or Notch to Remember. Trends in Neurosciences, 28: 429-35.
  • Costa R.M.*, Cohen D.*, Nicolelis M.A.L. (2004). Differential corticostriatal plasticity during fast and slow motor skill learning in mice. Current Biology, 14(13): 1124-34.
  • Costa R.M., Honjo T., and Silva A.J. (2003). Learning and memory deficitsin Notch mutant mice. Current Biology, 13 (15): 1348-54.
  • Costa R.M. and Silva A.J. (2003). Mouse models of Neurofibromatosis type I: Bridging the GAP. Trends in Molecular Medicine, 9: 19-23.
  • Costa R.M., Federov N.B., Kogan J.H., Murphy G.G., Stern, J., Ohno, M., Kucherlapati, R., Jacks, T. and Silva, A.J. (2002). Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature, 415 (6871): 526-30.
  • Costa R.M.*, Yang T.*, Huynh, D.P., Pulst S.M., Viskochil D.H., Silva A.J. and Brannan C.I. (2001). Learning deficits, but normal development and tumor predisposition, in mice lacking exon 23a of the Neurofibromatosis type I gene. Nature Genetics, 27: 399-405.

All Publications

  • Santos F.J., Costa R.M., Tecuapetla F. (2011). Stimulation on demand: closing the loop on deep brain stimulation, 72(2):197-8.
  • French C.A., Jin X., Campbell T.G., Gerfen E., Groszer M., Fisher S.E., Costa R.M. (2011). An aetiological Foxp2 mutation causes aberrant striatal activity and alters plasticity during skill learning. Molecular Psychiatry. doi: 10.1038/mp.2011.105
  • Costa R.M. (2011). A selectionist account of de novo action learning. Current Opinion in Neurobiology, 21(4):579-86.
  • Koralek A.C., Long J.D., Costa R.M., Carmena J.M. (2010). Corticostriatal dynamics during learning and performance of a neuroprosthetic task. Conf Proc IEEE Eng Med Biol Soc. 2010:2682-5
  • Dias-Ferreira E., Sousa N., Costa R.M. (2010). Frontocerebellar Connectivity: Climbing through the Inferior Olive. Frontiers in Neuroscience, 4. pii: 37. doi: 10.3389/fnins.2010.00037
  • Derusso A.L., Fan D., Gupta J., Shelest O., Costa R.M., Yin H.H. (2010). Instrumental uncertainty as a determinant of behavior under interval schedules of reinforcement. Frontiers in Integrative Neuroscience, 28;4. pii: 17,doi: 10.3389/fnint.2010.00017
  • Jin X. & Costa R.M. (2010). Start/stop signals emerge in nigrostriatal circuits during sequence learning. Nature, 466(7305): 457-62, doi:10.1038/nature09263
  • Venkatraman S., Jin X., Costa R.M., Carmena J.M. (2010). Investigating neural correlates of behavior in freely behaving rodents using inertial sensors. Journal of Neurophysiology, 104(1):569-75, doi: 10.1152/jn.00121.2010
  • Burkhardt J.M., Jin X, and Costa R.M (2009). Dissociable effects of dopamine on the firing rate and synchrony of striatal ensembles. Front. Integr. Neurosci., 3:28. doi: 10.3389/neuro.07.028.2009.
  • Dias-Ferreira E., Sousa J.C., Melo I., Morgado P., Mesquit, A.R., Cerqueira J.J., Costa R.M., Sousa N. (2009). Chronic stress causes frontostriatal reorganization and impairs decision making. Science, 325(5940):621-5.
  • Yin H.H., Prasad-Mulcare S., Hilario M.R.F., Clouse E., Davis M. I., Lovinger D.M., Costa R.M. (2009). Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill. Nature Neuroscience, 12:3.
  • Cui Y., Costa R. M., Murphy G. G., Elgersma Y., Zhu Y., Gutmann D.H., Parada L.F., Mody I., Silva A. J. (2008). Neurofibromin regulation of Ras/ERK signaling modulates GABA release and learning. Cell, 31;135(3):549-60.
  • Hilário M.R.F and Costa R.M. (2008). High on Habits. Frontiers in Neuroscience, 2,2:208-21.
  • Groszer M., Keays D.A., Deacon R.M.J., de Bono J.P., Prasad-Mulcare S., Gaub S., Baum M.G., French C.A., Nicod J., Coventry J.A., Enard W., Fray M., Brown S.D.M., Nolan P.M., Pääbo S., Channon K.M., Costa R.M., Eilers J., Ehret G.J., Rawlins N.P., Fisher S.E. (2008). Impaired motor learning and synaptic plasticity in mice carrying a point mutation implicated in human speech deficits. Current Biology, 18(5): 354-62.
  • Hilario M., Clouse E., Yin H.H., Costa R.M. (2007) Endocannabinoid signaling is critical for habit formation, Frontiers in Integrative Neuroscience 1: 6, doi: 10.3389/neuro.07/006.
  • Wickens J.R., Horvitz J.C., Costa R.M., Killcross S. (2007) Dopaminergic mechanisms in actions and habits, Journal of Neuroscience 27: 8181-3.
  • Costa R.M. (2007) Plastic corticostriatal circuits for action learning: What’s dopamine got to do with it?, Annals of the New York Academy of Sciences, 1104: 172-91.
  • Dzirasa K., Ribeiro S., Costa R.M., Santos L.M., Lin S.C., Grosmark A., Sotnikova T.D., Gainetdinov R.R., Caron M.G., Nicolelis M.A.L. (2006) Dopaminergic Control of Sleep-Wake States, Journal of Neuroscience, 26(41): 10577-89.
  • Costa R.M., Lin S.C., Sotnikova T.D., Cyr M., Gainetdinov R.R., Caron M.G., Nicolelis M.A.L. (2006) Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction. Neuron 52(2): 359-69.
  • Costa R.M., Gutierrez R., Kloth A., Coelho M.R.P., de Araujo I.E., Gainetdinov R.R., Caron M.G., Nicolelis M.A.L., Simon, S.A. (2006) Dopamine levels modulate the updating of tastant values. Genes, Brain and Behavior. 6(4): 314-20.
  • Nagy V., Bozdagi O., Matynia A., Balcerzyk M., Okulski P., Dzwonek J., Costa R.M., Silva A. J., Kaczmarek L., and Huntley G.W. (2006) Matrix metalloproteinase (MMP)-9 is required for hippocampal late-phase LTP and memory. Journal of Neuroscience 26: 1923-1934.
  • Costa R.M., Liu L., Nicolelis M.A.L., Simon S.A. (2005) Gustatory Effects of Capsaicin that are Independent of TRPV1 Receptors. Proc. ISOT XIV, Chemical Senses 30 S1: i198-i200.
  • Costa R.M., Drew C. and Silva A.J. (2005) To Remember or Notch to Remember. Trends in Neurosciences, 28: 429-35.
  • Costa R.M. and Silva A.J. (2004) Learning Deficits associated with NF1: from models to therapies. in Neurofibromatose: Clínica, Genética e Terapêutica , Ed. Mauro Geller, Editora Guanabara Koogan SA , Rio de Janeiro, Brazil (Portuguese).
  • Costa R.M., Cohen D., Nicolelis M.A.L. (2004) Differential corticostriatal plasticity during fast and slow motor skill learning in mice. Current Biology 14(13): 1124-34.
  • Israely I., Costa R.M., Silva A.J., Kosik K., Liu, X. (2004) Deletion of the neural specific protein Delta-Catenin leads to severe cognitive and synaptic dysfunction. Current Biology 14(18): 1657-63.
  • Ajay A., Costa R.M., Irvin D., Patel A., Hu H., Kornblum H., Silva A.J., O’Dell T., and Colicelli J. (2003). The RAS Effector RIN1 Modulates the Formation of Aversive Memories, Journal of Neuroscience, 23 (3): 748-757.
  • Frankland P.W., Ohno M., Takahashi E., Chen A.P., Costa R.M., Kushner S.A. and Silva A.J. (2003). Synomics: Pharmacologically Regulated Induction of Silent Mutations (PRISM): Combined pharmacological and genetic approaches for learning and memory. , The Neuroscientist, 9: 104-9.
  • Costa R.M., Honjo T., and Silva A.J. (2003) Learning and memory deficits in Notch mutant mice. Current Biology 13 (15): 1348-54.
  • Costa R.M. and Silva A.J. (2003) Mouse models of Neurofibromatosis type I: Bridging the GAP. Trends in Molecular Medicine, 9: 19-23.
  • Costa R.M., Elgersma Y. and Silva A.J. (2003. of Neurobehavioral Disorders, Ed. Gene Fisch, Humana Press, Totowa, NJ, USA.
  • Costa R.M., Federov N.B., Kogan J.H., Murphy G.G., Stern J., Ohno M., Kucherlapati R., Jacks T. and Silva A.J. (2002) Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1, Nature, 415 (6871) 415 (6871): 526-30.
  • Costa R.M. (2002) Molecular and cellular mechanisms of cognitive dysfunction in Neurofibromatosis type I. Thesis. Abel Salazar Biomedical Institute, University of Porto, Portugal.
  • Costa R.M. and Silva A.J. (2002) Molecular and cellular mechanisms underlying the cognitive deficits associated with Neurofibromatosis type I, Journal of Child Neurology, 17: 622-626.
  • Givogri M.I., Costa R.M., Schonmann V., Howard S., Silva A.J., Campagnoni A.T., Bongarzone E.R. (2002) The Jagged/Notch pathway is critical for oligodendrocyte differentiation and myelination in vivo., Journal of Neuroscience Research, 67 (3): 309-20.
  • Costa R.M., Yang T., Huynh D.P., Pulst S.M., Viskochil D.H., Silva A.J. and Brannan C.I. (2001) Learning deficits, but normal development and tumor predisposition, in mice lacking exon 23a of the Neurofibromatosis type I gene, Nature Genetics, 27: 399-405.
  • Silva A.J., Elgersma Y. and Costa R.M. (2001) From genes to therapies: the role of animal models. Clinical Neuroscience Research, 1: 187-193.
  • Ohno M., Frankland P.W., Chen P.A., Costa R.M. and Silva A.J. (2001) Inducible pharmacogenetic approaches to the study of learning and memory. Nature Neuroscience, 4: 1238-1243.
  • Silva A.J., Elgersma Y. and Costa R.M. (2000) Molecular and Cellular Mechanisms of Cognitive Function: Implications for Psychiatric Disorders., Biological Psychiatry, 47: 200-210.
  • Mayntz M. and Costa R. (1998) Effect of pharmacologically induced changes of ejection on suckling in Bos taurus. , Physiology and Behavior, 65 (1): 151-156.
  • Costa R., Mayntz M. and Sende, G. (1998) Changes of milk compounds and fatty acid composition during suckling meals and the effect of after-stimulation on fatty acid composition in cows’ milk. A pre-study. Milchwissenchaft, 53 (8): 430-434.

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